Norfloxacin: Uses, Dosage, Side Effects, and More

Norfloxacin is a fluoroquinolone antibiotic used to treat a variety of bacterial infections. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination. This inhibition prevents the bacteria from multiplying and spreading, effectively treating the infection. In this comprehensive blog post, we’ll explore the uses, dosage, side effects, and other important information about norfloxacin.

Uses of Norfloxacin

1. Urinary Tract Infections (UTIs): Norfloxacin is commonly prescribed for both uncomplicated and complicated urinary tract infections. It is effective against a broad spectrum of bacteria that cause UTIs, including Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis.
2. Prostatitis: Chronic bacterial prostatitis, an infection of the prostate gland, can be effectively treated with norfloxacin due to its ability to penetrate prostate tissue and eliminate the bacteria causing the infection.
3. Gastrointestinal Infections: Norfloxacin is used to treat gastrointestinal infections such as traveler’s diarrhea caused by susceptible strains of Escherichia coli. It helps reduce the severity and duration of diarrhea.
4. Sexually Transmitted Infections (STIs): Although less common, norfloxacin may be used to treat certain sexually transmitted infections, particularly when other first-line treatments are not suitable or effective.
5. Other Infections: Norfloxacin may also be prescribed for other types of infections, such as those affecting the respiratory tract or skin, although it is less commonly used for these purposes due to the availability of more targeted antibiotics.

Dosage of Norfloxacin

The dosage of norfloxacin varies based on the type and severity of the infection, the patient’s age, kidney function, and other medical conditions. Below are general guidelines:

Oral Dosage:

1. Urinary Tract Infections (UTIs):

• Uncomplicated UTIs:
  • Adults: 400 mg twice daily for 3-7 days.
• Complicated UTIs:
  • Adults: 400 mg twice daily for 7-14 days.

2. Prostatitis:

• Adults: 400 mg twice daily for 4-6 weeks.

3. Gastrointestinal Infections:

• Traveler’s Diarrhea:
  • Adults: 400 mg twice daily for 3-5 days.

Dosage Adjustments: Patients with impaired kidney function may require dosage adjustments. It’s crucial to follow a healthcare provider’s guidance in such cases. For patients with creatinine clearance less than 30 mL/min, the usual dose is 400 mg once daily.

Side Effects of Norfloxacin

Common Side Effects:

• Gastrointestinal Issues: Nausea, diarrhea, stomach pain, and dyspepsia are common side effects.
• Central Nervous System Effects: Headache, dizziness, and insomnia can occur.
• Skin Reactions: Rash, itching, and photosensitivity (increased sensitivity to sunlight) are possible.
• Tendinitis and Tendon Rupture: Fluoroquinolones, including norfloxacin, have been associated with an increased risk of tendinitis and tendon rupture, particularly in older adults and those taking corticosteroids.

Serious Side Effects:

• Peripheral Neuropathy: This condition involves nerve damage that can cause pain, burning, tingling, or numbness, potentially resulting in permanent damage.
• Central Nervous System Effects: Severe side effects include seizures, tremors, and confusion.
• Cardiac Effects: Norfloxacin can cause QT interval prolongation, leading to arrhythmias. Patients with a history of heart conditions should be monitored closely.
• Hypersensitivity Reactions: Severe allergic reactions, including anaphylaxis, can occur. Symptoms include rash, itching, swelling (especially of the face/tongue/throat), severe dizziness, and difficulty breathing.

Special Considerations

Pregnancy and Breastfeeding: Norfloxacin is classified as Category C for pregnancy by the FDA, indicating that risk cannot be ruled out. Animal studies have shown adverse effects, and there are no well-controlled studies in pregnant women

Also read: Levofloxacin Tablet: Uses, Side Effects, Dosage, Precautions and More