Letroz Tablet – Uses, Side Effects, Dosage, Precautions, and More

Letroz 2.5 mg tablet, containing the active ingredient letrozole, is a medication primarily used in the treatment of certain types of breast cancer in postmenopausal women. Letrozole belongs to a class of drugs known as aromatase inhibitors, which work by decreasing the amount of estrogen produced by the body. This reduction in estrogen can help slow or reverse the growth of hormone receptor-positive breast cancer cells.

Uses

1. Breast Cancer Treatment: Letrozole is most commonly prescribed to treat hormone receptor-positive breast cancer in postmenopausal women. It is often used:
   • As an adjuvant treatment following surgery to reduce the risk of cancer recurrence.
   • As
     

     a first-line treatment for metastatic breast cancer.

   • To treat advanced breast cancer that has progressed following treatment with other medications.
2. Fertility Treatment: Off-label, letrozole is sometimes used to induce ovulation in women with certain types of infertility, particularly those with polycystic ovary syndrome (PCOS).

Dosage

The dosage of Letroz 2.5 mg tablet is typically individualized based on the patient’s condition and response to treatment. However, standard dosing guidelines include:

1. For Breast Cancer:
   • The usual recommended dose is 2.5 mg once daily.
   • It can be taken with or without food.
   • Treatment duration varies based on the patient’s condition and response, but it can be administered for several years in the adjuvant setting.
2. For Infertility (off-label use):
   • The dosage may vary, but a common regimen is 2.5 mg to 5 mg taken for 5 days, starting on the third or fifth day of the menstrual cycle.

Administration Tips:

• Take the tablet at the same time each day to maintain an even level in your blood.
• Swallow the tablet whole with a glass of water.
• Do not crush or chew the tablet.

Side Effects

Like all medications, Letroz 2.5 mg tablet can cause side effects. While not everyone experiences them, it’s essential to be aware of potential adverse reactions:

1. Common Side Effects:
   • Hot flashes
   • Joint or muscle pain
   • Fatigue
   • Sweating
   • Nausea
   • Headache
2. Less Common Side Effects:
   • Bone thinning (osteoporosis) and increased risk of fractures
   • Increased cholesterol levels
   • Weight gain
   • Edema (swelling in the hands, feet, or legs)
   • Depression or mood changes
   • Insomnia
3. Serious Side Effects (seek medical attention if these occur):
   • Severe bone pain
   • Shortness of breath
   • Swelling of the face, lips, or tongue
   • Yellowing of the skin or eyes (jaundice)
   • Chest pain or signs of a heart attack or stroke

Precautions and Warnings

1. Allergies: Inform your doctor if you have a known allergy to letrozole or any other ingredients in the tablet.
2. Bone Health: Since letrozole can lead to bone thinning, patients with osteoporosis or those at risk should be monitored regularly.
3. Cholesterol Levels: Letrozole can increase cholesterol levels; periodic blood tests may be necessary to monitor lipid profiles.
4. Pregnancy and Breastfeeding: Letrozole is contraindicated in premenopausal women and during pregnancy due to potential harm to the fetus. It should also not be used while breastfeeding.
5. Liver Function: Patients with liver impairment should use letrozole with caution, and dose adjustments may be necessary.
6. Interactions: Inform your doctor of all medications you are taking, as letrozole can interact with certain drugs, including hormone replacement therapy and tamoxifen.

Price and Availability

The price of Letroz 2.5 mg tablet can vary based on the manufacturer, region, and pharmacy. On average, the cost can range from $10 to $50 for a month’s supply. It’s advisable to check with local pharmacies for exact pricing and to explore options for generic versions, which can be more affordable.

Conclusion

Letroz 2.5 mg tablet is a crucial medication in the management of hormone receptor-positive breast cancer in postmenopausal women. Its effectiveness in reducing estrogen levels helps in slowing down or reversing the growth of cancer cells. While it has potential side effects, careful monitoring and adherence to prescribed dosages can mitigate many risks. Always consult with a healthcare professional before starting or adjusting any medication regimen, and report any adverse effects promptly to ensure the best possible outcome in your treatment journey.

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