Overview
Cefo Plus (Medley) Tablet is an antibiotic formulation that contains two active ingredients:
- Cefixime (100 mg): A third-generation cephalosporin antibiotic effective against a wide range of bacteria.
- Ofloxacin (100 mg): A fluoroquinolone antibiotic with broad-spectrum bactericidal activity.
Indications
Cefo Plus (Medley) Tablet is prescribed for the treatment of:
- Respiratory Tract Infections: Including bronchitis and community-acquired pneumonia.
- Urinary Tract Infections: Such as cystitis and pyelonephritis.
- Sexually Transmitted Infections: Including gonorrhea.
- Enteric Fever: Caused by Salmonella typhi.
- Skin and Soft Tissue Infections: Such as cellulitis and impetigo.
Mechanism of Action
- Cefixime: Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell death.
- Ofloxacin: Inhibits bacterial DNA gyrase and topoisomerase IV enzymes, interfering with bacterial DNA replication, transcription, repair, and recombination.
Dosage and Administration
- The typical adult dosage of Cefo Plus (Medley) Tablet is one tablet (Cefixime 100 mg + Ofloxacin 100 mg) twice daily or as directed by a physician.
- It should be taken orally with plenty of fluids.
- Dosage adjustments may be required in patients with renal impairment.
Contraindications
- Hypersensitivity: Individuals with a history of hypersensitivity to cephalosporins, fluoroquinolones, or any component of the formulation should avoid this medication.
- Pregnancy and Lactation: Use with caution during pregnancy and lactation under strict medical supervision.
Adverse Effects
Common adverse effects of Cefo Plus (Medley) Tablet include:
- Gastrointestinal: Nausea, vomiting, diarrhea, abdominal pain.
- Central Nervous System: Headache, dizziness.
- Skin: Rash, itching.
- Others: Hypersensitivity reactions, superinfections.
Precautions
- Use caution in patients with a history of seizures or central nervous system disorders.
- Avoid concurrent use with antacids, as they may interfere with the absorption of Ofloxacin.
Drug Interactions
- Antacids: May reduce the absorption of Ofloxacin.
- Probenecid: Can increase the concentration of Cefixime by reducing its renal clearance.
- Warfarin: Enhanced anticoagulant effect when used concomitantly with Ofloxacin.
Overdosage
- In case of overdosage, symptomatic and supportive treatment should be provided. Consultation with a healthcare professional is advised.
Storage
- Store Cefo Plus (Medley) Tablet at room temperature (20-25°C), away from moisture and direct sunlight.
- Keep out of reach of children and pets.
Conclusion
Cefo Plus (Medley) Tablet is a combination antibiotic effective against a wide range of bacterial infections. It should only be used under medical supervision and as prescribed. Adherence to dosage and precautions is essential to maximize therapeutic benefits while minimizing adverse effects. Always consult with a healthcare provider for personalized medical advice regarding its use.
This comprehensive overview covers the key aspects of Cefo Plus (Medley) Tablet, providing essential information for understanding its indications, mechanisms, dosages, and safety considerations.
Disclaimer:
All information and content on this site are provided for informational and educational purposes only. They are not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare professional for any health-related concerns or conditions.
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