Domperidone : Uses, Side Effects, Dosage, Precautions and More

Domperidone is a medication commonly used to relieve nausea and vomiting, as well as to enhance gastrointestinal motility. This blog post aims to provide comprehensive information on Domperidone tablets, covering their uses, side effects, dosage, precautions, and more.

1. Introduction to Domperidone

Domperidone is an antiemetic and prokinetic agent, primarily used to treat symptoms of nausea and vomiting. It is also used to enhance gastrointestinal motility in conditions where there is slowed movement of the stomach and intestines.

2. Uses of Domperidone Tablets

• Nausea and Vomiting: Domperidone is widely used to treat nausea and vomiting caused by various conditions, including gastrointestinal disorders, migraines, and chemotherapy.
• Gastroesophageal Reflux Disease (GERD): It helps in managing symptoms of GERD by promoting faster gastric emptying.
• gastroparesis: Domperidone is effective in treating gastroparesis, a condition where the stomach cannot empty itself of food normally.
• Lactation: Occasionally, Domperidone is used off-label to enhance lactation in breastfeeding mothers by increasing prolactin levels.

3. How Domperidone Works

Domperidone works by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) and in the stomach. This action prevents nausea signals from reaching the brain and increases gastrointestinal motility, aiding in faster gastric emptying and reducing symptoms of bloating and discomfort.

4. Dosage of Domperidone Tablets

The dosage of Domperidone varies depending on the condition being treated and the patient’s age and weight. It is crucial to follow a healthcare provider’s instructions when taking Domperidone.

• Adults: The typical dosage for adults is 10 mg taken two to three times daily before meals.
• Children: Dosage for children is determined by their weight, usually 0.25 mg/kg taken three times daily.
• Maximum Dosage: The maximum recommended dose for adults is 30 mg per day.

5. Side Effects of Domperidone

While Domperidone is generally well-tolerated, it can cause side effects in some individuals. Common side effects include:

• Headache: Some users may experience headaches.
• Dry Mouth: A feeling of dryness in the mouth is relatively common.
• Abdominal Cramps: Some patients report abdominal discomfort or cramps.
• Diarrhea: Loose stools or diarrhea may occur.

Less common but more serious side effects include:

• Cardiac Effects: Domperidone has been associated with an increased risk of cardiac arrhythmias, particularly in older adults or those taking higher doses.
• Allergic Reactions: Rarely, allergic reactions such as rash, itching, or swelling can occur.

6. Precautions and Warnings

Before starting Domperidone, it is essential to consider certain precautions and discuss them with a healthcare provider:

• Heart Conditions: Patients with a history of heart disease or arrhythmias should use Domperidone cautiously, as it can affect heart rhythm.
• Liver Impairment: Those with liver conditions may require adjusted dosages or alternative treatments.
• Pregnancy and Breastfeeding: Domperidone should only be used during pregnancy and breastfeeding if deemed necessary by a healthcare provider.
• Drug Interactions: Domperidone can interact with other medications, such as ketoconazole, erythromycin, and certain antidepressants, increasing the risk of adverse effects.

7. How to Take Domperidone Tablets

Domperidone tablets should be taken as directed by a healthcare provider. Here are some general guidelines:

• Timing: Take Domperidone 15 to 30 minutes before meals and, if needed, before bedtime.
• Consistency: Take the medication at the same times each day to maintain an even level in your bloodstream.
• Missed Dose: If you miss a dose, take it as soon as you remember unless it is nearly time for your next dose. Do not double up to make up for a missed dose.

8. Overdose and Emergency Measures

In case of an overdose, it is crucial to seek immediate medical attention. Symptoms of overdose may include severe dizziness, fainting, or irregular heartbeat. Emergency measures may involve gastric lavage, activated charcoal, and symptomatic treatment.

9. Storage and Handling

Store Domperidone tablets at room temperature, away from moisture and heat. Keep the medication out of reach of children and pets.

10. Frequently Asked Questions (FAQs)

Q1: Can I drink alcohol while taking Domperidone? A1: It is advisable to avoid alcohol while taking Domperidone, as alcohol can exacerbate side effects such as dizziness and drowsiness.

Q2: Can Domperidone be taken long-term? A2: Domperidone is generally prescribed for short-term use. Long-term use should be monitored by a healthcare provider due to potential risks.

Q3: Is Domperidone safe for elderly patients? A3: Elderly patients may be more susceptible to side effects, particularly cardiac arrhythmias. A lower dose or alternative treatment may be considered.

Q4: Can Domperidone be used in children? A4: Yes, Domperidone can be used in children, but the dosage must be carefully adjusted based on the child’s weight and health condition.

11. Conclusion

Domperidone is a valuable medication for managing nausea, vomiting, and gastrointestinal motility disorders. While it is generally safe and effective, it is essential to use it under the guidance of a healthcare provider, considering all precautions and potential side effects. If you have any concerns or experience any adverse effects while taking Domperidone, consult your healthcare provider promptly.

By understanding the uses, dosage, side effects, and precautions associated with Domperidone tablets, patients can use this medication safely and effectively to improve their quality of life.

Also read: Domperidone Tablet: Uses, Side Effects, Dosage, Precautions and More