Glycomet Tablet SR – Uses, Side Effects, Dosage, Precautions, and More

Glycomet 500 MG Tablet SR is an oral medication primarily used for the management of type 2 diabetes mellitus. It belongs to the class of drugs known as biguanides, which work by improving insulin sensitivity and reducing glucose production in the liver. The “SR” in its name stands for “sustained release,” indicating that the tablet is designed to release the medication slowly over time for a prolonged effect.

Uses

Glycomet 500 MG Tablet SR is mainly prescribed for:

1. Type 2 Diabetes Mellitus: It is used to control high blood sugar in patients with type 2 diabetes. Maintaining blood sugar levels can prevent complications such as kidney damage, blindness, nerve problems, and loss of limbs.
2. Polycystic Ovary Syndrome (PCOS): Sometimes used off-label to manage symptoms of PCOS, such as irregular menstrual cycles, by improving insulin resistance.

Mechanism of Action

Glycomet (Metformin) works through several mechanisms:

• Decreasing Hepatic Glucose Production: It reduces the amount of glucose produced by the liver.
• Improving Insulin Sensitivity: Enhances the sensitivity of muscle cells to insulin, thereby improving glucose uptake.
• Reducing Intestinal Absorption of Glucose: It decreases the absorption of glucose from the gastrointestinal tract.

Dosage and Administration

Standard Dosage

• Initial Dose: Typically, the starting dose is 500 mg once daily with the evening meal.
• Titration: The dose can be gradually increased by 500 mg weekly based on blood glucose levels and tolerability.
• Maximum Dose: The maximum recommended dose is 2000 mg per day, usually divided into two doses.

Administration Tips

• With Food: Glycomet should be taken with meals to reduce gastrointestinal side effects.
• Swallow Whole: Do not crush or chew the tablet as it is designed for sustained release.
• Consistent Timing: Take the medication at the same time each day to maintain even blood levels.

Side Effects

Like all medications, Glycomet 500 MG Tablet SR can cause side effects. Most are mild and may improve over time as the body adjusts to the medication.

Common Side Effects

1. Gastrointestinal Issues: Nausea, vomiting, diarrhea, stomach pain, and loss of appetite. These symptoms are usually temporary and subside as the body adapts to the medication.
2. Metallic Taste: Some patients may experience a metallic taste in the mouth.

Serious Side Effects

1. Lactic Acidosis: A rare but serious side effect. Symptoms include muscle pain, trouble breathing, stomach pain, dizziness, and feeling cold. It requires immediate medical attention.
2. Vitamin B12 Deficiency: Long-term use may reduce vitamin B12 absorption, leading to deficiency. Regular monitoring is recommended.

Precautions and Warnings

Before Taking Glycomet

• Allergies: Inform your doctor if you are allergic to metformin or any other ingredients in the tablet.
• Medical History: Share your medical history, especially kidney disease, liver disease, heart disease, or any history of lactic acidosis.

During Treatment

• Kidney Function: Regular monitoring of kidney function is essential, as metformin is excreted through the kidneys.
• Surgical Procedures: Inform your doctor if you plan to undergo any surgery or radiological procedure involving contrast dye, as metformin may need to be temporarily discontinued.
• Alcohol Intake: Limit alcohol consumption, as it can increase the risk of lactic acidosis.

Interactions

Drug Interactions

Glycomet can interact with other medications, which may affect its efficacy or increase the risk of side effects.

1. Diuretics: Increase the risk of lactic acidosis.
2. Beta-Blockers: Can mask symptoms of low blood sugar.
3. Corticosteroids: May reduce the effectiveness of metformin by increasing blood sugar levels.

Food and Lifestyle Interactions

• Alcohol: Increases the risk of lactic acidosis.
• Diet: Maintain a balanced diet and monitor carbohydrate intake to manage blood sugar levels effectively.

Monitoring

Regular monitoring is crucial for patients on Glycomet 500 MG Tablet SR to ensure its effectiveness and safety.

1. Blood Glucose Levels: Regular self-monitoring of blood sugar levels is essential.
2. HbA1c Levels: Periodic testing of HbA1c levels provides an average blood sugar level over the past 2-3 months.
3. Kidney Function Tests: Regular tests to monitor kidney function, as metformin is excreted by the kidneys.
4. Vitamin B12 Levels: Long-term users should periodically check vitamin B12 levels.

Storage

• Temperature: Store at room temperature, away from direct light and moisture.
• Keep Out of Reach of Children: Ensure that the medication is kept in a secure place away from children.

Price and Availability

Glycomet 500 MG Tablet SR is widely available in pharmacies. Prices may vary based on the location and the pharmacy, but it is generally considered affordable.

Conclusion

Glycomet 500 MG Tablet SR is an effective medication for managing type 2 diabetes and, in some cases, PCOS. It helps control blood sugar levels, thereby preventing complications associated with diabetes. However, it is essential to follow the prescribed dosage, adhere to dietary recommendations, and monitor health parameters regularly. Patients should also be aware of potential side effects and interactions with other medications. Always consult a healthcare provider for personalized advice and treatment plans.

Also read: Lactic Acid Bacillus – Uses, Dosage, Side Effects